Kratom – Neurotoxic Or Cardiotoxic?

Much focus is placed on the human brain and heart. These organs are vital to human life and if one of them is not working properly, it will be difficult to live a normal life. Millions of people around the globe are living with some type of heart condition.

Alzheimer’s disease, a group of brain disorders that affect both social and intellectual skills, is also causing concern among middle-aged women and men.

Cardiac arrest is a condition that frightens everyone. And, no one wants to loose their ability to function normally and remember the most important details of their life.

As Kratom continues to grow in popularity, a large number of individuals are questioning whether Kratom is a neurotoxic or cardiotoxic. There is much literature available that explains the health benefits of Kratom in detail, as well as its potential for such toxicity.

Individuals who have found relief from Kratom have also taken the time to write articles and testimonials about their experiences.

Kratom’s Cardiotoxicity More In-Depth

Cariotoxicity refers to the occurrence of heart muscle damage or electrophysiology dysfunction. When the heart muscles are damaged, the flow of blood from the chambers to the ventricles of the heart will be interrupted.

Specific drugs, exposure to heavy metals and chemotherapy can cause harm to the heart muscles. Kratom’s cardiotoxicity is not clear, but a few users have self-reported seizure activity.

Some experts believe the seizures are related to a combination of Kratom’s active alkaloids and other substances, such as Propylhexedrine and O-desmethytramadol.

These substances have allegedly been found in over-the-counter supplements claiming to be made of “pure” Kratom. Nine deaths related to these supplements have been reported in Sweden alone.

In such cases, it was determined that the acute toxicity was not a result of Kratom consumption. In fact, the adverse reactions, such as seizure activity, were caused by a combination of Kratom active alkaloids and other compounds, such as Datura Stramonium and Modafinil.

A study utilizing cardiomyocytes derived from human induced pluripotent stem cells have accessed Kratom’s cardiotoxicity, focusing mainly on its analogues and Mitragynine, an alkaloid.

Even with the results of that study, it is still unclear if Kratom’s primary alkaloid, Mitragynine, is a cardiotoxic. The researchers conducting the study noted as much in their final report.

However, the study still found that Kratom inhibited specific cardiomyocytes, producing a cardiotoxic effect. Of course, the level of alkaloid consumed by the average user could not be accurately determined.

Several commonly used stimulates, such as caffeine, also produce a cardiotoxic effect, when they are consumed in large doses. Experts believe that these stimulants are safe for human consumption and are not cardiotoxic, when they are utilized in moderation and responsibly.

It is important, when consuming Kratom to follow the dosage recommendations to a tee. Since there is not scientific evidence available to determine if Kratom is utilized in moderate doses that it is a cardiotoxic.

Is It True That Kratom Is Neurotoxic?

If you have been researching Kratom online there is a high change that you have come across tons of forums or websites saying that Kratom is neurotoxic, or at least encountered people discussing this topic.

In fact, one user on a Longecity forum created an extremely popular post called “Kratom-bad for intelligence/brain/neurotoxic?”

During this post the user completely slams the herb and states that if the herb isn’t neurotoxic then he was going to abuse it on a regular basis.

Another use replied that if Kratom was neurotoxic then she was going to be in serious trouble, because she has been taking it for a number of years on a daily basis to help keep her Rheumatoid Arthritis symptoms at bay.

Taking this herb prevents her from having to turn to pain medications.

Another user quickly responded to both of the posts and said that Kratom isn’t neurotoxic, but it is cardiotoxic. However, someone responded to this post with proof that the user who died while taking Kratom was mixing other medications as well. In fact, the autopsy in this very case reported findings of Kratom and O-desmethyltramadol.

A recent report has been published stating that individuals that are consuming Kratom with other substances are at a higher risk of developing neurotoxicity. This is why it is imperative that anyone using the herb makes sure that they use it in moderation and only as prescribed.

How Does Kratom Affect The Brain?

Every since the discovery of Kratom scientists and researchers alike have been evaluating and studying that actions that Kratom’s bioactive alkaloids are having on the brain. What is known so far is that when taking Kratom it hits the same receptors in the brain that opioids hit.

And, this is what really makes this herb such a powerful tool when it comes to treating opioid addiction and withdrawal symptoms.

In addition to this, these are the very properties that allow Kratom to be used as an anti-anxiety medication and mood enhancer. Also, when this herb is administered in lowers doses it can even give off the same effects as a stimulant, which is why a lot of individual report heightened energy and alertness when taking the herb.

What Can Kratom Treat?

It really is no big secret that Kratom has been used for thousands of years as a folk medicine. It has been administered to a variety of individuals that were suffering from various illnesses like diabetes, chronic pain, neuropathy, and depression.

When it comes to being used as an analgesic, this powerful herb can help with a wide range of different pain conditions like migraines, arthritis, inflammation, joint pain, and chronic fatigue syndrome.

Along with this, over the past few years the herb has even become widely known for treating diarrhea conditions.

A Quick Recap

When Kratom is taken as prescribed for the prescribed amount of time there really is no proof that it has neurotoxic effects. Anyone that is really concerned with overdosing or being left with a hangover should just make sure that they stick to responsible administration.

Only use the herb in moderation and make sure that you are cycling on and off as recommended.

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